Tumor Immune Profiling-Based Neoadjuvant Immunotherapy for Locally Advanced Melanoma.

ABSTRACT:

Background

The frequency of "exhausted" or checkpoint-positive (PD-1⁺CTLA-4⁺) cytotoxic lymphocytes (Tex) in the tumor microenvironment is associated with response to anti-PD-1 therapy in metastatic melanoma. The current study determined whether pretreatment Tex cells in locally advanced melanoma predicted response to neoadjuvant anti-PD-1 blockade.

Methods

Pretreatment tumor samples from 17 patients with locally advanced melanoma underwent flow cytometric analysis of pretreatment Tex and regulatory T cell frequency. Patients who met the criteria for neoadjuvant checkpoint blockade were treated with either PD-1 monotherapy or PD-1/CTLA-4 combination therapy. Best overall response was evaluated by response evaluation criteria in solid tumors version 1.1,

SUBMITTER: Levine LS 

PROVIDER: S-EPMC8317618 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature