FGF21/adiponectin ratio predicts deterioration in glycemia: a 4.6-year prospective study in China.

ABSTRACT:

Background

The fibroblast growth factor (FGF) 21-adiponectin pathway is involved in the regulation of insulin resistance. However, the relationship between the FGF21-adiponectin pathway and type 2 diabetes in humans is unclear. Here, we investigated the association of FGF21/adiponectin ratio with deterioration in glycemia in a prospective cohort study.

Methods

We studied 6361 subjects recruited from the prospective Shanghai Nicheng Cohort Study in China. The association between baseline FGF21/adiponectin ratio and new-onset diabetes and incident prediabetes was evaluated using multiple logistic regression analysis.

Results

At baseline, FGF21/adiponectin ratio levels increased progressively with the deterioration in glycemic control from normal glucose tolerance to pre

SUBMITTER: Liu D 

PROVIDER: S-EPMC8320224 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature