Pan-cancer analysis of m⁵C regulator genes reveals consistent epigenetic landscape changes in multiple cancers.

ABSTRACT:

Background

5-Methylcytosine (m⁵C) is a reversible modification to both DNA and various cellular RNAs. However, its roles in developing human cancers are poorly understood, including the effects of mutant m⁵C regulators and the outcomes of modified nucleobases in RNAs.

Methods

Based on The Cancer Genome Atlas (TCGA) database, we uncovered that mutations and copy number variations (CNVs) of m⁵C regulatory genes were significantly correlated across many cancer types. We then assessed the correlation between the expression of individual m⁵C regulators and the activity of related hallmark pathways of cancers.

Results

After validating m⁵C regulators' expression based on their contributions to cancer development and prog

SUBMITTER: He Y 

PROVIDER: S-EPMC8323224 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature