Reward drinking and naltrexone treatment response among young adult heavy drinkers.

ABSTRACT:

Aims

Theory-driven, exploratory study to: (i) identify a reward drinking phenotype in young adults; (ii) evaluate this phenotype as a predictor of naltrexone response; and (iii) examine mechanisms of naltrexone in reward drinkers.

Design

Secondary analysis of a randomized controlled trial.

Setting

USA.

Participants

A total of 128 young adult (ages 18-25) heavy drinkers.

Interventions

Naltrexone versus placebo.

Measurements

Daily surveys assessed affect, urge, drinking, and context. The Drinking Motives Questionnaire was used to identify phenotypes based on reward (enhancement motives) and relief (coping motives) drinking.

Findings

We identified three profiles: "Low reward/Low relief" (14.1%; low enhancement/low coping motives); "Reward drin

SUBMITTER: Roos CR 

PROVIDER: S-EPMC8328878 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature