Mismatch Repair Status Correlates with Survival in Young Adults with Metastatic Colorectal Cancer.

ABSTRACT:

Background

Young adults with metastatic colorectal cancer (mCRC) may have higher rates of deficient mismatch repair (dMMR) than older patients. This study sought to assess patterns of MMR-testing and survival among young adult mCRC patients in the National Cancer Database (NCDB), hypothesizing that dMMR correlates with worse survival than in MMR-proficient (pMMR) patients.

Methods

Stage-IV colorectal cancers were identified in NCDB (2010-2016). Demographic and clinical features were compared between younger (age ≤ 30) and older mCRC patients and tested for association with overall survival. Stage-IV disease without other recorded metastatic sites defined peritoneal metastasis (PM). Fisher-exact tests compared proportions and Cox models tested association with overall surviva

SUBMITTER: van der Heide DM 

PROVIDER: S-EPMC8338754 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature