Validation of the mean systemic filling pressure assessment with preserved arterial blood flow by comparing two methods of calculation.

ABSTRACT: We developed a method for measuring in vivo venular volumes and the mean systemic filling pressure in the limbs using near-infrared spectroscopy (NIRS). We aimed to validate the NIRS methodology by comparing two independent methods of calculation based on different physiological approaches. Pressure-volumes (P-V) curves were recorded following graded venous occlusion on the forearm. Values from a P-V curves analysis model (method 1) were compared with data derived from a resistor-capacitance calculation model (method 2) based on arterial pressure and venous compliance. We tested these methods on 10 healthy participants at rest and during exercise and on 6 severely ill patients. Results from method 1 were comparable with those calculated by method 2. Venular volumes calculated using method

SUBMITTER: De Blasi RA 

PROVIDER: S-EPMC8338930 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature