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A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging.

ABSTRACT: Transition-metal chalcogenide compounds with facile preparation and multifunctional elements act as ideal photothermal agents for cancer theranostics. This work synthesizes Cu_7.2S₄/5MoS₂ composite nanoflowers and investigates the crystal growth mechanism to optimize the synthesis strategy and obtain excellent photothermal therapy agents. Cu_7.2S₄/5MoS₂ exhibits a high photothermal conversion efficiency of 58.7% and acts as a theranostic nanoplatform and demonstrated an effective photothermal-chemodynamic-photodynamic synergetic therapeutic effect in both in vitro and in vivo tests. Moreover, Cu_7.2S₄/5MoS₂ shows strong photoacoustic signal amplitudes and computed tomographic contrast enhancement in vivo. These results suggest a potential application of Cu_7.2S₄/5MoS₂ composite nanoflowers as photo/H₂O₂-responsive therapeutic agents against tumors.

SUBMITTER: Wu M

PROVIDER: S-EPMC8339317 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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A Near-Infrared Light Triggered Composite Nanoplatform for Synergetic Therapy and Multimodal Tumor Imaging.

Wu Mingzhou M He Shuqing S Hu Xin X Chen Jingqin J Ha Enna E Ai Fujin F Ji Tao T Hu Junqing J Ruan Shuangchen S

Frontiers in chemistry 20210722

Transition-metal chalcogenide compounds with facile preparation and multifunctional elements act as ideal photothermal agents for cancer theranostics. This work synthesizes Cu7.2S4/5MoS2 composite nanoflowers and investigates the crystal growth mechanism to optimize the synthesis strategy and obtain excellent photothermal therapy agents. Cu7.2S4/5MoS2 exhibits a high photothermal conversion efficiency of 58.7% and acts as a theran ...[more]

PMID: 34368079

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