COVID-19-associated inhibition of energy accumulation pathways in human semen samples.

ABSTRACT:

Objective

To investigate transcriptional alterations in human semen samples associated with COVID-19 infection.

Design

Retrospective observational cohort study.

Setting

City hospital.

Patients

Ten patients who had recovered from mild COVID-19 infection. Eight of these patients had different sperm abnormalities that were diagnosed before infection. The control group consisted of 5 healthy donors without known abnormalities and no history of COVID-19 infection.

Interventions

We used RNA sequencing to determine gene expression profiles in all studied biosamples. Original standard bioinformatic instruments were used to analyze activation of intracellular molecular pathways.

Main outcome measures

Routine semen analysis, gene expression levels, and mole

SUBMITTER: Adamyan L 

PROVIDER: S-EPMC8339600 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature