Dataset Information

ACO2 clinicobiological dataset with extensive phenotype ontology annotation.

ABSTRACT: Pathogenic variants of the aconitase 2 gene (ACO2) are responsible for a broad clinical spectrum involving optic nerve degeneration, ranging from isolated optic neuropathy with recessive or dominant inheritance, to complex neurodegenerative syndromes with recessive transmission. We created the first public locus-specific database (LSDB) dedicated to ACO2 within the "Global Variome shared LOVD" using exclusively the Human Phenotype Ontology (HPO), a standard vocabulary for describing phenotypic abnormalities. All the variants and clinical cases listed in the literature were incorporated into the database, from which we produced a dataset. We followed a rational and comprehensive approach based on the HPO thesaurus, demonstrating that ACO2 patients should not be classified separately between isolated and syndromic cases. Our data highlight that certain syndromic patients do not have optic neuropathy and provide support for the classification of the recurrent pathogenic variants c.220C>G and c.336C>G as likely pathogenic. Overall, our data records demonstrate that the clinical spectrum of ACO2 should be considered as a continuum of symptoms and refines the classification of some common variants.

SUBMITTER: Guehlouz K

PROVIDER: S-EPMC8342444 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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ACO2 clinicobiological dataset with extensive phenotype ontology annotation.

Guehlouz Khadidja K Foulonneau Thomas T Amati-Bonneau Patrizia P Charif Majida M Colin Estelle E Bris Céline C Desquiret-Dumas Valérie V Milea Dan D Gohier Philippe P Procaccio Vincent V Bonneau Dominique D den Dunnen Johan T JT Lenaers Guy G Reynier Pascal P Ferré Marc M

Scientific data 20210805 1

Pathogenic variants of the aconitase 2 gene (ACO2) are responsible for a broad clinical spectrum involving optic nerve degeneration, ranging from isolated optic neuropathy with recessive or dominant inheritance, to complex neurodegenerative syndromes with recessive transmission. We created the first public locus-specific database (LSDB) dedicated to ACO2 within the "Global Variome shared LOVD" using exclusively the Human Phenotype Ontology (HPO), a standard vocabulary for describing phenotypic a ...[more]

PMID: 34354088

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Dataset Information

ACO2 clinicobiological dataset with extensive phenotype ontology annotation.

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ACO2 clinicobiological dataset with extensive phenotype ontology annotation.

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