Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population.

ABSTRACT:

Introduction

Although lower high-density lipoprotein cholesterol (HDL-C) levels are considered a risk factor for cardiovascular disease (CVD), experimental evidence suggest that aging, inflammation, and oxidative stress may remodel HDL-C, leading to dysfunctional HDL-C. Population studies on HDL-C and loss of the glomerular filtration rate (GFR) reported inconsistent results, but they used inaccurate estimates of the GFR and may have been confounded by comorbidity.

Methods

We investigated the association of HDL-C levels with risk of GFR loss in a general population cohort; the participants were aged 50-62 years and did not have diabetes, CVD, or chronic kidney disease (CKD) at baseline. The GFR was measured using iohexol-clearance at baseline (n=1627) and at the follo

SUBMITTER: Melsom T 

PROVIDER: S-EPMC8343778 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature