Cytokine-Laden Extracellular Vesicles Predict Patient Prognosis after Cerebrovascular Accident.

ABSTRACT: A major contributor to disability after hemorrhagic stroke is secondary brain damage induced by the inflammatory response. Following stroke, global increases in numerous cytokines-many associated with worse outcomes-occur within the brain, cerebrospinal fluid, and peripheral blood. Extracellular vesicles (EVs) may traffic inflammatory cytokines from damaged tissue within the brain, as well as peripheral sources, across the blood-brain barrier, and they may be a critical component of post-stroke neuroinflammatory signaling. We performed a comprehensive analysis of cytokine concentrations bound to plasma EV surfaces and/or sequestered within the vesicles themselves. These concentrations were correlated to patient acute neurological condition by the Glasgow Coma Scale (GCS) and to chronic, lo

SUBMITTER: Fringuello A 

PROVIDER: S-EPMC8345931 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature