Ontology highlight
ABSTRACT:
SUBMITTER: Park JY
PROVIDER: S-EPMC8345984 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Park Jun-Young JY Choi Hyun-Ju HJ Park Tamina T Lee Moon-Jo MJ Lim Hak-Seong HS Yang Woong-Suk WS Hwang Cher-Won CW Park Daeui D Kim Cheorl-Ho CH
International journal of molecular sciences 20210722 15
Melanin causes melasma, freckles, age spots, and chloasma. Anti-melanogenic agents can prevent disease-related hyperpigmentation. In the present study, the dose-dependent tyrosinase inhibitory activity of Avenanthramide (Avn)-A-B-C was demonstrated, and 100 µM Avn-A-B-C produced the strongest competitive inhibition against inter-cellular tyrosinase and melanin synthesis. Avn-A-B-C inhibits the expression of melanogenesis-related proteins, such as TRP1 and 2. Molecular docking simulation revealed ...[more]