Ontology highlight
ABSTRACT:
SUBMITTER: Sun D
PROVIDER: S-EPMC8349880 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Sun Daochun D Xie Xuanhua P XP Zhang Xiyuan X Wang Zilai Z Sait Sameer Farouk SF Iyer Swathi V SV Chen Yu-Jung YJ Brown Rebecca R Laks Dan R DR Chipman Mollie E ME Shern Jack F JF Parada Luis F LF
Cell stem cell 20210518 8
NF1-associated malignant peripheral nerve sheath tumors (MPNSTs) are the major cause of mortality in neurofibromatosis. MPNSTs arise from benign peripheral nerve plexiform neurofibromas that originate in the embryonic neural crest cell lineage. Using reporter transgenes that label early neural crest lineage cells in multiple NF1 MPNST mouse models, we discover and characterize a rare MPNST cell population with stem-cell-like properties, including quiescence, that is essential for tumor initiatio ...[more]