Association of SUMOylation Pathway Genes With Stroke in a Genome-Wide Association Study in India.

ABSTRACT:

Objective

To undertake a genome-wide association study (GWAS) to identify genetic variants for stroke in an Indian population.

Methods

In a hospital-based case-control study, 8 teaching hospitals in India recruited 4,088 participants, including 1,609 stroke cases. Imputed genetic variants were tested for association with stroke subtypes using both single-marker and gene-based tests. Association with vascular risk factors was performed with logistic regression. Various databases were searched for replication, functional annotation, and association with related traits. Status of candidate genes previously reported in the Indian population was also checked.

Results

Associations of vascular risk factors with stroke were similar to previous reports and show modifiable risk

SUBMITTER: Kumar A 

PROVIDER: S-EPMC8362360 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature