Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation.

ABSTRACT: Allergic airway inflammation is driven by type-2 CD4⁺ T cell inflammatory responses. We uncover an immunoregulatory role for the nucleotide release channel, Panx1, in T cell crosstalk during airway disease. Inverse correlations between Panx1 and asthmatics and our mouse models revealed the necessity, specificity, and sufficiency of Panx1 in T cells to restrict inflammation. Global Panx1^-/- mice experienced exacerbated airway inflammation, and T-cell-specific deletion phenocopied Panx1^-/- mice. A transgenic designed to re-express Panx1 in T cells reversed disease severity in global Panx1^-/- mice. Panx1 activation occurred in pro-inflammatory T effector (Teff) and inhibitory T regulatory (Treg) cells and mediated the extracellular-nucleotide-based

SUBMITTER: Medina CB 

PROVIDER: S-EPMC8363584 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature