Preserved Mucosal-Associated Invariant T-Cell Numbers and Function in Idiopathic CD4 Lymphocytopenia.

ABSTRACT:

Background

Mucosal-associated invariant T (MAIT) cells constitute a subset of unconventional, MR1-restricted T cells involved in antimicrobial responses as well as inflammatory, allergic, and autoimmune diseases. Chronic infection and inflammatory disorders as well as immunodeficiencies are often associated with decline and/or dysfunction of MAIT cells.

Methods

We investigated the MAIT cells in patients with idiopathic CD4+ lymphocytopenia (ICL), a syndrome characterized by consistently low CD4 T-cell counts (<300 cell/µL) in the absence of HIV infection or other known immunodeficiency, and by susceptibility to certain opportunistic infections.

Results

The numbers, phenotype, and function of MAIT cells in peripheral blood were preserved in ICL patients compared to hea

SUBMITTER: Sortino O 

PROVIDER: S-EPMC8366440 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature