Synthesis and biological evaluation of N ⁶ derivatives of 8-azapurine as novel antiplatelet agents.

ABSTRACT: Two series of novel N ⁶ derivatives of 8-azapurine I and II were designed as antiplatelet agents. Series I and II were N ⁶ amino derivatives and N ⁶ hydrazone derivatives of 8-azapurine, respectively. The compounds were synthesized in acceptable yields via conventional procedures, including nucleophilic substitution, diazotization, and amination or hydrazonation with amino alcohol and 4,6-dichloropyrimidine as starting materials. To assess the ability of the synthesized compounds as antiplatelet agents, the ADP-induced platelet aggregation assay of Born was performed both in vitro and in vivo using ticagrelor as a reference control substance. The analysis of the structure-activity relatio

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC8372213 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature