Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy.

ABSTRACT: Men with castration-resistant prostate cancer (CRPC) face poor prognosis and increased risk of treatment-incurred adverse effects resulting in one of the highest mortalities among patient population globally. Immune cells act as double-edged sword depending on the tumor microenvironment, which leads to increased infiltration of pro-tumor (M2) macrophages. Development of new immunomodulatory therapeutic agents capable of targeting the tumor microenvironment, and hence orchestrating the transformation of pro-tumor M2 macrophages to anti-tumor M1, would substantially improve treatment outcomes of CRPC patients. We report, herein, Mangiferin functionalized gold nanoparticulate agent (MGF-AuNPs) and its immunomodulatory characteristics in treating prostate cancer. We provide evidence of immunom

SUBMITTER: Khoobchandani M 

PROVIDER: S-EPMC8373987 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature