Sex-Specific Social Behavior and Amygdala Proteomic Deficits in Foxp2 ^+/- Mutant Mice.

ABSTRACT: In humans, mutations in the transcription factor encoding gene, FOXP2, are associated with language and Autism Spectrum Disorders (ASD), the latter characterized by deficits in social interactions. However, little is known regarding the function of Foxp2 in male or female social behavior. Our previous studies in mice revealed high expression of Foxp2 within the medial subnucleus of the amygdala (MeA), a limbic brain region highly implicated in innate social behaviors such as mating, aggression, and parental care. Here, using a comprehensive panel of behavioral tests in male and female Foxp2 ^+/- heterozygous mice, we investigated the role Foxp2 plays in MeA-linked innate social behaviors. We reveal significant deficits in olfactory processing, social i

SUBMITTER: Herrero MJ 

PROVIDER: S-EPMC8374433 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature