Cannabis sativa and/or melatonin do not alter brain lipid but alter oxidative mechanisms in female rats.

ABSTRACT:

Background

Lipid profile and redox status play a role in brain (dys)functions. Cannabinoid and melatonergic systems operate in the brain and contribute to brain (patho)physiology, but their roles in the modulation of brain lipid and redox status are not well-known. We studied the effect of ethanol extract of Cannabis sativa (CS) and/or melatonin (M) on the lipid profile and anti-oxidant system of the rat brain.

Methods

We randomly divided twenty-four (24) female Wistar rats into 4 groups (n = 6 rats each). Group 1 (control) received distilled water mixed with DMSO. Groups II-IV received CS (2 mg/kg), M (4 mg/kg), and co-administration of CS and M (CS + M) respectively via oral gavage between 8:00 am and 10:00 am once daily for 14 days. Animals underwent 12-h fasting after th

SUBMITTER: Abdulrahim HA 

PROVIDER: S-EPMC8377844 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature