A glycosyltransferase gene signature to detect pancreatic ductal adenocarcinoma patients with poor prognosis.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an important heterogeneity, reflected by different clinical outcomes and chemoresistance. During carcinogenesis, tumor cells display aberrant glycosylated structures, synthetized by deregulated glycosyltransferases, supporting the tumor progression. In this study, we aimed to determine whether PDAC could be stratified through their glycosyltransferase expression profiles better than the current binary classification (basal-like and classical) in order to improve detection of patients with poor prognosis.

Methods

Bioinformatic analysis of 169 glycosyltransferase RNA sequencing data were performed for 74 patient-derived xenografts (PDX) of resected and unresectable tumors. The Australian cohort of Internati

SUBMITTER: Mohamed Abd-El-Halim Y 

PROVIDER: S-EPMC8379629 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature