Biomarkers of Kidney Tubule Health, CKD Progression, and Acute Kidney Injury in SPRINT (Systolic Blood Pressure Intervention Trial) Participants.

ABSTRACT:

Rationale & objective

The Systolic Blood Pressure Intervention Trial (SPRINT) compared the effect of intensive versus standard systolic blood pressure targets on cardiovascular morbidity and mortality. In this ancillary study, we evaluated the use of exploratory factor analysis (EFA) to combine biomarkers of kidney tubule health in urine and plasma and then study their role in longitudinal estimated glomerular filtration rate (eGFR) change and risk of acute kidney injury (AKI).

Study design

Observational cohort nested in a clinical trial.

Setting & participants

2,351 SPRINT participants with eGFR < 60 mL/min/1.73 m² at baseline.

Exposure

Levels of neutrophil gelatinase-associated lipocalin (NGAL), interleukin 18 (IL-18), chitinase-3-like protein (YKL

SUBMITTER: Bullen AL 

PROVIDER: S-EPMC8384678 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature