Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers.

ABSTRACT:

Purpose

The Primary Immune Deficiency Treatment Consortium (PIDTC) enrolled children with severe combined immunodeficiency (SCID) in a prospective natural history study of hematopoietic stem cell transplant (HSCT) outcomes over the last decade. Despite newborn screening (NBS) for SCID, infections occurred prior to HSCT. This study's objectives were to define the types and timing of infection prior to HSCT in patients diagnosed via NBS or by family history (FH) and to understand the breadth of strategies employed at PIDTC centers for infection prevention.

Methods

We analyzed retrospective data on infections and pre-transplant management in patients with SCID diagnosed by NBS and/or FH and treated with HSCT between 2010 and 2014. PIDTC centers were surveyed in 2018 to understa

SUBMITTER: Dorsey MJ 

PROVIDER: S-EPMC8388237 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature