Maternal P7C3-A20 Treatment Protects Offspring from Neuropsychiatric Sequelae of Prenatal Stress.

ABSTRACT: Aims: Impaired embryonic cortical interneuron development from prenatal stress is linked to adult neuropsychiatric impairment, stemming in part from excessive generation of reactive oxygen species in the developing embryo. Unfortunately, there are no preventive medicines that mitigate the risk of prenatal stress to the embryo, as the underlying pathophysiologic mechanisms are poorly understood. Our goal was to interrogate the molecular basis of prenatal stress-mediated damage to the embryonic brain to identify a neuroprotective strategy. Results: Chronic prenatal stress in mice dysregulated nicotinamide adenine dinucleotide (NAD⁺) synthesis enzymes and cortical interneuron development in the embryonic brain, leading to axonal degeneration in the hippo

SUBMITTER: Schroeder R 

PROVIDER: S-EPMC8388250 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature