Ontology highlight
ABSTRACT:
SUBMITTER: Lee WHK
PROVIDER: S-EPMC8390872 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Lee Wen Hao Kenneth WHK Liu Wei W Fan Jing-Song JS Yang Daiwen D
Biophysical journal 20210422 12
The viral protease domain (NS3pro) of dengue virus is essential for virus replication, and its cofactor NS2B is indispensable for the proteolytic function. Although several NS3pro-NS2B complex structures have been obtained, the dynamic property of the complex remains poorly understood. Using NMR relaxation techniques, here we found that NS3pro-NS2B exists in both closed and open conformations that are in dynamic equilibrium on a submillisecond timescale in aqueous solution. Our structural inform ...[more]