Order from Disorder with Intrinsically Disordered Peptide Amphiphiles.

ABSTRACT: Amphiphilic molecules and their self-assembled structures have long been the target of extensive research due to their potential applications in fields ranging from materials design to biomedical and cosmetic applications. Increasing demands for functional complexity have been met with challenges in biochemical engineering, driving researchers to innovate in the design of new amphiphiles. An emerging class of molecules, namely, peptide amphiphiles, combines key advantages and circumvents some of the disadvantages of conventional phospholipids and block copolymers. Herein, we present new peptide amphiphiles composed of an intrinsically disordered peptide conjugated to two variants of hydrophobic dendritic domains. These molecules, termed intrinsically disordered peptide amphiphiles (IDPA),

SUBMITTER: Jacoby G 

PROVIDER: S-EPMC8397319 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature