Alzheimer's Pathology Is Associated with Dedifferentiation of Intrinsic Functional Memory Networks in Aging.
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ABSTRACT:
SUBMITTER: Cassady KE
PROVIDER: S-EPMC8408467 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Alzheimer's Pathology Is Associated with Dedifferentiation of Intrinsic Functional Memory Networks in Aging.
Cassady Kaitlin E KE Adams Jenna N JN Chen Xi X Maass Anne A Harrison Theresa M TM Landau Susan S Baker Suzanne S Jagust William W
Cerebral cortex (New York, N.Y. : 1991) 20210801 10
In presymptomatic Alzheimer's disease (AD), beta-amyloid plaques (Aβ) and tau tangles accumulate in distinct spatiotemporal patterns within the brain, tracking closely with episodic memory decline. Here, we tested whether age-related changes in the segregation of the brain's intrinsic functional episodic memory networks-anterior-temporal (AT) and posterior-medial (PM) networks-are associated with the accumulation of Aβ, tau, and memory decline using fMRI and PET. We found that AT and PM networks ...[more]
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