EvoProDom: evolutionary modeling of protein families by assessing translocations of protein domains.

ABSTRACT: Here, we introduce a novel 'evolution of protein domains' (EvoProDom) model for describing the evolution of proteins based on the 'mix and merge' of protein domains. We assembled and integrated genomic and proteomic data comprising protein domain content and orthologous proteins from 109 organisms. In EvoProDom, we characterized evolutionary events, particularly, translocations, as reciprocal exchanges of protein domains between orthologous proteins in different organisms. We showed that protein domains that translocate with highly frequency are generated by transcripts enriched in trans-splicing events, that is, the generation of novel transcripts from the fusion of two distinct genes. In EvoProDom, we describe a general method to collate orthologous protein annotation from KEGG, and prot

SUBMITTER: Carmi G 

PROVIDER: S-EPMC8409312 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature