Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.

ABSTRACT:

Background

Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading to severe clinical course in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human leukocyte antigen alleles (HLA) have been suggested as potential genetic host factors that affect individual immune response to SARS-CoV-2. We sought to evaluate this hypothesis by conducting a multicenter study using HLA sequencing.

Methods

We analyzed the association between COVID-19 severity and HLAs in 435 individuals from Germany (n = 135), Spain (n = 133), Switzerland (n = 20) and the United States (n = 147), who had been enrolled from March 2020 to Augu

SUBMITTER: Weiner J 

PROVIDER: S-EPMC8410317 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature