Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke.

ABSTRACT:

Background

Neonatal stroke affects 1 in 2800 live births and is a major cause of neurological injury. The Sonic hedgehog (Shh) signaling pathway is critical for central nervous system (CNS) development and has neuroprotective and reparative effects in different CNS injury models. Previous studies have demonstrated beneficial effects of small molecule Shh-Smoothened agonist (SAG) against neonatal cerebellar injury and it improves Down syndrome-related brain structural deficits in mice. Here we investigated SAG neuroprotection in rat models of neonatal ischemia-reperfusion (stroke) and adult focal white matter injury.

Methods

We used transient middle cerebral artery occlusion at P10 and ethidium bromide (EB) injection in adult rats to induce damage. Following surgery and SAG o

SUBMITTER: Nguyen V 

PROVIDER: S-EPMC8410885 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature