Ontology highlight
ABSTRACT:
SUBMITTER: Zheng Q
PROVIDER: S-EPMC8418205 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Zheng Qinheng Q Xu Hongtao H Wang Hua H Du Wen-Ge Han WH Wang Nan N Xiong Huan H Gu Yuang Y Noodleman Louis L Sharpless K Barry KB Yang Guang G Wu Peng P
Journal of the American Chemical Society 20210225 10
The lack of efficient [<sup>18</sup>F]fluorination processes and target-specific organofluorine chemotypes remains the major challenge of fluorine-18 positron emission tomography (PET). We report here an ultrafast isotopic exchange method for the radiosynthesis of novel PET agent aryl [<sup>18</sup>F]fluorosulfate enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully automated <sup>18</sup>F-radiolabeling of 25 structurally and functio ...[more]