Dataset Information

Reduction of Tissue Na⁺ Accumulation After Renal Transplantation.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) engenders salt-sensitive hypertension. Whether or not tissue Na⁺ accumulation is increased in CKD patients remains uncertain. How tissue Na⁺ is affected after renal transplantation has not been assessed.

Methods

We measured tissue Na⁺ amount in 31 CKD patients (stage 5) and prospectively evaluated tissue Na⁺ content at 3 and 6 months, following living-donor kidney transplantation. Additionally, pre- and post-transplantation data were compared to 31 age- and sex-matched control subjects. ²³Na-magnetic resonance imaging (²³Na-MRI) was used to quantify muscle and skin Na⁺ of the lower leg and water distribution was assessed by bioimpedance spectroscopy.

Results

Compared to control subjects, CKD patients showed increased muscle (20.7 ± 5.0 vs. 15.5 ± 1.8 arbitrary units [a.u.], P < 0.001) and skin Na⁺ content (21.4 ± 7.7 vs. 15.0 ± 2.3 a.u., P < 0.001), whereas plasma Na⁺ concentration did not differ between groups. Restoration of kidney function by successful renal transplantation was accompanied by mobilization of tissue Na⁺ from muscle (20.7 ± 5.0 vs. 16.8 ± 2.8 a.u., P < 0.001) and skin tissue (21.4 ± 7.7 vs. 16.8 ± 5.2 a.u., P < 0.001). The reduction of tissue Na⁺ after transplantation was associated with improved renal function, normalization of blood pressure as well as an increase in lymphatic growth-factor concentration (vascular endothelial growth factor C [VEGF-C] 4.5 ± 1.8 vs. 6.7 ± 2.7 ng/ml, P < 0.01).

Conclusions

Tissue Na⁺ accumulation in predialysis patients with CKD was almost completely reversed to the level of healthy controls after successful kidney transplantation.

SUBMITTER: Dahlmann A

PROVIDER: S-EPMC8418983 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Publications

Reduction of Tissue Na<sup>+</sup> Accumulation After Renal Transplantation.

Dahlmann Anke A Linz Peter P Zucker Isabelle I Haag Viktor V Jantsch Jonathan J Dienemann Thomas T Nagel Armin M AM Neubert Patrick P Rosenhauer Daniela D Rauh Manfred M Horn Stephan S Müller Dominik N DN Schiffer Mario M Luft Friedrich C FC Uder Michael M Kopp Christoph C

Kidney international reports 20210628 9

<h4>Introduction</h4>Chronic kidney disease (CKD) engenders salt-sensitive hypertension. Whether or not tissue Na<sup>+</sup> accumulation is increased in CKD patients remains uncertain. How tissue Na<sup>+</sup> is affected after renal transplantation has not been assessed.<h4>Methods</h4>We measured tissue Na<sup>+</sup> amount in 31 CKD patients (stage 5) and prospectively evaluated tissue Na<sup>+</sup> content at 3 and 6 months, following living-donor kidney transplantation. Additionally, p ...[more]

PMID: 34514195

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Dataset Information

Reduction of Tissue Na⁺ Accumulation After Renal Transplantation.

Introduction

Methods

Results

Conclusions

Publications

Reduction of Tissue Na<sup>+</sup> Accumulation After Renal Transplantation.

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Dataset Information

Reduction of Tissue Na+ Accumulation After Renal Transplantation.

Introduction

Methods

Results

Conclusions

Publications

Reduction of Tissue Na<sup>+</sup> Accumulation After Renal Transplantation.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Reduction of Tissue Na⁺ Accumulation After Renal Transplantation.