Reduction of Tissue Na⁺ Accumulation After Renal Transplantation.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) engenders salt-sensitive hypertension. Whether or not tissue Na⁺ accumulation is increased in CKD patients remains uncertain. How tissue Na⁺ is affected after renal transplantation has not been assessed.

Methods

We measured tissue Na⁺ amount in 31 CKD patients (stage 5) and prospectively evaluated tissue Na⁺ content at 3 and 6 months, following living-donor kidney transplantation. Additionally, pre- and post-transplantation data were compared to 31 age- and sex-matched control subjects. ²³Na-magnetic resonance imaging (²³Na-MRI) was used to quantify muscle and skin Na⁺ of the lower leg and water distribution was assessed by bioimpedance spectroscopy.

Resu

SUBMITTER: Dahlmann A 

PROVIDER: S-EPMC8418983 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature