Identification of a Locus Near <i>ULK1</i> Associated With Progression-Free Survival in Ovarian Cancer.

ABSTRACT:

Background

Many loci have been found to be associated with risk of epithelial ovarian cancer (EOC). However, although there is considerable variation in progression-free survival (PFS), no loci have been found to be associated with outcome at genome-wide levels of significance.

Methods

We carried out a genome-wide association study (GWAS) of PFS in 2,352 women with EOC who had undergone cytoreductive surgery and standard carboplatin/paclitaxel chemotherapy.

Results

We found seven SNPs at 12q24.33 associated with PFS (P < 5 × 10^-8), the top SNP being rs10794418 (HR = 1.24; 95% CI, 1.15-1.34; P = 1.47 × 10^-8). High expression of a nearby gene, ULK1, is associated with shorter PFS in EOC, and with poor prognosis in other cancers

SUBMITTER: Quinn MCJ 

PROVIDER: S-EPMC8419101 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature