Dataset Information

Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection.

ABSTRACT:

Background

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a complex antibody response that varies by orders of magnitude between individuals and over time.

Methods

We developed a multiplex serological test for measuring antibodies to 5 SARS-CoV-2 antigens and the spike proteins of seasonal coronaviruses. We measured antibody responses in cohorts of hospitalized patients and healthcare workers followed for up to 11 months after symptoms. A mathematical model of antibody kinetics was used to quantify the duration of antibody responses. Antibody response data were used to train algorithms for estimating time since infection.

Results

One year after symptoms, we estimate that 36% (95% range, 11%-94%) of anti-Spike immunoglobulin G (IgG) remains, 31% (95% range, 9%-89%) anti-RBD IgG remains, and 7% (1%-31%) of anti-nucleocapsid IgG remains. The multiplex assay classified previous infections into time intervals of 0-3 months, 3-6 months, and 6-12 months. This method was validated using data from a seroprevalence survey in France, demonstrating that historical SARS-CoV-2 transmission can be reconstructed using samples from a single survey.

Conclusions

In addition to diagnosing previous SARS-CoV-2 infection, multiplex serological assays can estimate the time since infection, which can be used to reconstruct past epidemics.

SUBMITTER: Pelleau S

PROVIDER: S-EPMC8420633 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Publications

Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection.

Pelleau Stéphane S Woudenberg Tom T Rosado Jason J Donnadieu Françoise F Garcia Laura L Obadia Thomas T Gardais Soazic S Elgharbawy Yasmine Y Velay Aurelie A Gonzalez Maria M Nizou Jacques Yves JY Khelil Nizar N Zannis Konstantinos K Cockram Charlotte C Merkling Sarah Hélène SH Meola Annalisa A Kerneis Solen S Terrier Benjamin B de Seze Jerome J Planas Delphine D Schwartz Olivier O Dejardin François F Petres Stéphane S von Platen Cassandre C Pellerin Sandrine Fernandes SF Arowas Laurence L de Facci Louise Perrin LP Duffy Darragh D Cheallaigh Clíona Ní CN Dunne Jean J Conlon Niall N Townsend Liam L Duong Veasna V Auerswald Heidi H Pinaud Laurie L Tondeur Laura L Backovic Marija M Hoen Bruno B Fontanet Arnaud A Mueller Ivo I Fafi-Kremer Samira S Bruel Timothée T White Michael M

The Journal of infectious diseases 20211101 9

<h4>Background</h4>Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a complex antibody response that varies by orders of magnitude between individuals and over time.<h4>Methods</h4>We developed a multiplex serological test for measuring antibodies to 5 SARS-CoV-2 antigens and the spike proteins of seasonal coronaviruses. We measured antibody responses in cohorts of hospitalized patients and healthcare workers followed for up to 11 months after symptoms. A mathe ...[more]

PMID: 34282461

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Dataset Information

Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection.

Background

Methods

Results

Conclusions

Publications

Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection.

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