Reparative System Arising from CCR2(+) Monocyte Conversion Attenuates Neuroinflammation Following Ischemic Stroke.

ABSTRACT: Monocytes recruitment from the blood to inflamed tissues following ischemic stroke is an important immune response to wound healing and tissue repair. Mouse monocytes can be endogenously divided into two distinct populations: pro-inflammatory or classical monocytes that express CCR2^highCX3CR1^low and circulate in blood, and anti-inflammatory or non-classical monocytes that express CCR2^lowCX3CR1^high and patrol locally. In this study of transgenic mice with functional CX3CR1^GFP/+ or CX3CR1^GFP/+-CCR2^RFP/+, we found that CCR2^highCX3CR1^low monocytes recruited to the injured brain were cytokine-dependently converted into CCR2^lowCX3CR1^high macrophages, especially under the influ

SUBMITTER: Park J 

PROVIDER: S-EPMC8421302 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature