DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life.

ABSTRACT:

Aims/hypothesis

Among white European children developing type 1 diabetes, the otherwise common HLA haplotype DR15-DQ6 is rare, and highly protective. Adult-onset type 1 diabetes is now known to represent more overall cases than childhood onset, but it is not known whether DR15-DQ6 is protective in older-adult-onset type 1 diabetes. We sought to quantify DR15-DQ6 protection against type 1 diabetes as age of onset increased.

Methods

In two independent cohorts we assessed the proportion of type 1 diabetes cases presenting through the first 50 years of life with DR15-DQ6, compared with population controls. In the After Diabetes Diagnosis Research Support System-2 (ADDRESS-2) cohort (n = 1458) clinician-diagnosed type 1 diabetes was confirmed by positivity for one or more islet-s

SUBMITTER: Thomas NJ 

PROVIDER: S-EPMC8423681 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature