Citicoline Modulates Glaucomatous Neurodegeneration Through Intraocular Pressure-Independent Control.

ABSTRACT: Glaucoma is a neurodegenerative disease that causes progressive, irreversible vision loss. Currently, intraocular pressure (IOP) is the only modifiable risk factor for glaucoma. However, glaucomatous degeneration may continue despite adequate IOP control. Therefore, there exists a need for treatment that protects the visual system, independent of IOP. This study sought, first, to longitudinally examine the neurobehavioral effects of different magnitudes and durations of IOP elevation using multi-parametric magnetic resonance imaging (MRI), optokinetics and histology; and, second, to evaluate the effects of oral citicoline treatment as a neurotherapeutic in experimental glaucoma. Eighty-two adult Long Evans rats were divided into six groups: acute (mild or severe) IOP elevation, chronic (ci

SUBMITTER: van der Merwe Y 

PROVIDER: S-EPMC8423893 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature