Dataset Information

Epidemiology of Methicillin-Resistant Staphylococcus Aureus in Arab Countries of the Middle East and North African (MENA) Region.

ABSTRACT: Available data suggest a high burden of methicillin-resistant staphylococcus aureus (MRSA) in Arab countries of the Middle East and North Africa (MENA). To review the MRSA rates and molecular epidemiology in this region, we used PubMed search engine to identify relative articles published from January 2005 to December 2019. Great heterogeneity in reported rates was expectedly seen. Nasal MRSA colonization ranged from 2%-16% in Gulf Cooperation Council (GCC), 1-9% in the Levant, and 0.2%-9% in North African Arab states. Infective MRSA rates ranged from 9%-38% in GCC, 28%-67% in the Levant, and 28%-57% in North African states. Studies demonstrated a wide clonal diversity in the MENA. The most common molecular types belonged to 5 clonal complexes (CC) known to spread worldwide: CC5, CC8, CC22, CC30, and CC80. The most prevalent strains had genotypes related to the European community-acquired MRSA (CA-MRSA), Brazilian/Hungarian hospital-acquired MRSA (HA-MRSA), UK-EMRSA-15 HA-MRSA, and USA300 CA-MRSA. Finally, significant antimicrobial resistance was seen in the region with variation in patterns depending on location and clonal type. For a more accurate assessment of MRSA epidemiology and burden, the Arab countries need to implement national surveillance systems.

SUBMITTER: Tabaja H

PROVIDER: S-EPMC8425352 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Epidemiology of Methicillin-Resistant Staphylococcus Aureus in Arab Countries of the Middle East and North African (MENA) Region.

Tabaja Hussam H Hindy Joya-Rita JR Kanj Souha S SS

Mediterranean journal of hematology and infectious diseases 20210901 1

Available data suggest a high burden of methicillin-resistant <i>staphylococcus aureus</i> (MRSA) in Arab countries of the Middle East and North Africa (MENA). To review the MRSA rates and molecular epidemiology in this region, we used PubMed search engine to identify relative articles published from January 2005 to December 2019. Great heterogeneity in reported rates was expectedly seen. Nasal MRSA colonization ranged from 2%-16% in Gulf Cooperation Council (GCC), 1-9% in the Levant, and 0.2%-9 ...[more]

PMID: 34527202

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Project description:BackgroundThe epidemiology of Neisseria gonorrhoeae (NG) infection in the Middle East and North Africa (MENA) region remains poorly understood, despite the global recognition of its disease burden and the growing concern regarding antimicrobial resistance. This study aimed to systematically review the evidence on NG prevalence in MENA, estimate the pooled mean prevalence across different populations, and explore population-level associations with prevalence as well as sources of between-study heterogeneity.MethodsThe study conducted a systematic review, risk of bias assessment, meta-analyses, and meta-regressions, utilizing both published and unpublished evidence sourced from international, regional, and national databases, in adherence to PRISMA guidelines. Random-effects meta-analyses and meta-regressions were employed to analyze the data.ResultsThe study identified 341 NG prevalence measures from 21 countries in MENA. The pooled mean prevalence of current urogenital infection was 1.9% (95% confidence interval (CI) 1.1-2.8%) in the general population, with a higher pooled prevalence in studies with sample sizes < 200 (3.1%; 95% CI 1.5-5.0%) compared to those with sample sizes ≥ 200 (1.1%; 95% CI 0.5-1.9%). Among specific populations, the pooled prevalence was 6.5% (95% CI 4.4-9.0%) in female sex workers, 7.5% (95% CI 2.8-14.0%) in attendees of infertility clinics, 3.0% (95% CI 0.4-7.0%) in women with miscarriage or ectopic pregnancy, 3.9% (95% CI 2.7-5.3%) in symptomatic women, and 41.4% (95% CI 34.9-48.1%) in symptomatic men. For male sex workers and men who have sex with men, the pooled prevalence of current urogenital infection was 1.6% (95% CI 0.4-3.4%), while the prevalence of current anorectal infection was 10.4% (95% CI 4.6-18.0%). Through multivariable meta-regressions, 64% of the prevalence variation was explained, revealing a hierarchical pattern in prevalence by population type and sex, and a prevalence decline at a rate of 1% per year.ConclusionsNG prevalence in MENA is comparable to the global prevalence, underscoring a neglected and underrecognized disease burden, with social and economic consequences. Persistent transmission of NG among key populations and other populations at risk increases the potential for the emergence of new drug-resistant strains. MENA is far from achieving the World Health Organization's target of reducing NG incidence by 90% by 2030.

Dataset Information

Epidemiology of Methicillin-Resistant Staphylococcus Aureus in Arab Countries of the Middle East and North African (MENA) Region.

Publications

Epidemiology of Methicillin-Resistant Staphylococcus Aureus in Arab Countries of the Middle East and North African (MENA) Region.

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