Ontology highlight
ABSTRACT:
SUBMITTER: Carey CM
PROVIDER: S-EPMC8429143 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Carey Clayton M CM Apple Sarah E SE Hilbert Zoë A ZA Kay Michael S MS Elde Nels C NC
Cell host & microbe 20210805 9
The pathogenesis of infectious diarrheal diseases is largely attributed to enterotoxins that cause dehydration by disrupting intestinal water absorption. We investigated patterns of genetic variation in mammalian guanylate cyclase-C (GC-C), an intestinal receptor targeted by bacterially encoded heat-stable enterotoxins (STa), to determine how host species adapt in response to diarrheal infections. Our phylogenetic and functional analysis of GC-C supports long-standing evolutionary conflict with ...[more]