Invariant natural killer T-cell subsets have diverse graft-versus-host-disease-preventing and antitumor effects.

ABSTRACT: Invariant natural killer T (iNKT) cells are a T-cell subset with potent immunomodulatory properties. Experimental evidence in mice and observational studies in humans indicate that iNKT cells have antitumor potential as well as the ability to suppress acute and chronic graft-versus-host-disease (GVHD). Murine iNKT cells differentiate during thymic development into iNKT1, iNKT2, and iNKT17 sublineages, which differ transcriptomically and epigenomically and have subset-specific developmental requirements. Whether distinct iNKT sublineages also differ in their antitumor effect and their ability to suppress GVHD is currently unknown. In this work, we generated highly purified murine iNKT sublineages, characterized their transcriptomic and epigenomic landscape, and assessed specific functions.

SUBMITTER: Maas-Bauer K 

PROVIDER: S-EPMC8432044 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature