Integrated dynamic wet spinning of core-sheath hydrogel fibers for optical-to-brain/tissue communications.

ABSTRACT: Hydrogel optical light-guides have received substantial interest for applications such as deep-tissue biosensors, optogenetic stimulation and photomedicine due to their biocompatibility, (micro)structure control and tissue-like Young's modulus. However, despite recent developments, large-scale fabrication with a continuous synthetic methodology, which could produce core-sheath hydrogel fibers with the desired optical and mechanical properties suitable for deep-tissue applications, has yet to be achieved. In this study, we report a versatile concept of integrated light-triggered dynamic wet spinning capable of continuously producing core-sheath hydrogel optical fibers with tunable fiber diameters, and mechanical and optical propagation properties. Furthermore, this concept also exhibited ve

SUBMITTER: Chen G 

PROVIDER: S-EPMC8433079 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature