Biocompatible Micron-Scale Silk Fibers Fabricated by Microfluidic Wet Spinning.

ABSTRACT: For successful material deployment in tissue engineering, the material itself, its mechanical properties, and the microscopic geometry of the product are of particular interest. While silk is a widely applied protein-based tissue engineering material with strong mechanical properties, the size and shape of artificially spun silk fibers are limited by existing processes. This study adjusts a microfluidic spinneret to manufacture micron-sized wet-spun fibers with three different materials enabling diverse geometries for tissue engineering applications. The spinneret is direct laser written (DLW) inside a microfluidic polydimethylsiloxane (PDMS) chip using two-photon lithography, applying a novel surface treatment that enables a tight print-channel sealing. Alginate, polyacrylonitrile, and si

SUBMITTER: Luken A 

PROVIDER: S-EPMC11468244 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature