Dataset Information

Comparison of Skin Antiseptic Agents and the Role of 0.01% Hypochlorous Acid.

ABSTRACT:

Background

Hypochlorous acid (HA) has both anti-microbial and wound-healing properties with a growing role for utilization in pre-procedural care on the face.

Objectives

The authors sought to compare the antiseptic property of 0.01% HA solution, 5% povidone iodine (PI), 4% chlorhexidine gluconate (CHG), and 70% isopropyl alcohol (IPA) antiseptic on facial skin.

Methods

This was a prospective single-center clinical trial.

Results

A total of 21 participants were recruited. Bacterial growth was seen in CHG (10%), IPA (71%), PI (81%), and HA (95%) of specimens (P < 0.001). CHG had less growth compared with HA (P = <0.001), IPA (P = <0.001), and PI (P = <0.001). No difference in bacterial growth was noted between HA and IPA (P = 0.063) or HA and PI (P = 0.25). Significant differences in mono-microbial and poly-microbial growth were seen between HA and IPA (P = 0.046) and HA and CHG (P = <0.001). Staphylococcus epidermidis grew less frequently in CHG (10%), followed by IPA (29%), PI (71%), and HA (71%). Staphylococcus capitis grew less frequently in CHG (0%), followed by PI (14%), HA (24%), and IPA (29%).

Conclusions

CHG reduced the bacterial growth compared with HA, PI, and IPA. However, HA, PI, and IPA had insignificant differences in bactericidal effects. Our study provides a supporting role of HA to be considered as an antiseptic.

Level of evidence: 2

SUBMITTER: Tran AQ

PROVIDER: S-EPMC8438591 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Publications

Comparison of Skin Antiseptic Agents and the Role of 0.01% Hypochlorous Acid.

Tran Ann Q AQ Topilow Nicole N Rong Andrew A Persad Patrice J PJ Lee Michael C MC Lee James H JH Anagnostopoulos Apostolos G AG Lee Wendy W WW

Aesthetic surgery journal 20210901 10

<h4>Background</h4>Hypochlorous acid (HA) has both anti-microbial and wound-healing properties with a growing role for utilization in pre-procedural care on the face.<h4>Objectives</h4>The authors sought to compare the antiseptic property of 0.01% HA solution, 5% povidone iodine (PI), 4% chlorhexidine gluconate (CHG), and 70% isopropyl alcohol (IPA) antiseptic on facial skin.<h4>Methods</h4>This was a prospective single-center clinical trial.<h4>Results</h4>A total of 21 participants were recrui ...[more]

PMID: 33247899

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Dataset Information

Comparison of Skin Antiseptic Agents and the Role of 0.01% Hypochlorous Acid.

Background

Objectives

Methods

Results

Conclusions

Level of evidence: 2

Publications

Comparison of Skin Antiseptic Agents and the Role of 0.01% Hypochlorous Acid.

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