PathFams: statistical detection of pathogen-associated protein domains.

ABSTRACT:

Background

A substantial fraction of genes identified within bacterial genomes encode proteins of unknown function. Identifying which of these proteins represent potential virulence factors, and mapping their key virulence determinants, is a challenging but important goal.

Results

To facilitate virulence factor discovery, we performed a comprehensive analysis of 17,929 protein domain families within the Pfam database, and scored them based on their overrepresentation in pathogenic versus non-pathogenic species, taxonomic distribution, relative abundance in metagenomic datasets, and other factors.

Conclusions

We identify pathogen-associated domain families, candidate virulence factors in the human gut, and eukaryotic-like mimicry domains with likely roles in virulence.

SUBMITTER: Lobb B 

PROVIDER: S-EPMC8442362 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature