HPV16 E6-specific T cell response and HLA-A alleles are related to the prognosis of patients with cervical cancer.

ABSTRACT:

Background

T cell epitopes are polypeptide fragments presented to T cell receptors by MHC molecules encoded by human leukocyte antigen (HLA) genes after antigen-presenting cell processing, which is the basis for the study of antigen immune mechanism and multi-epitope vaccine. This study investigated T cell response to HPV16 E6 and E7 in patients with cervical squamous cell carcinoma (CSCC). Also, the HLA-A allele distribution was compared among patients and evaluated as a factor to predict prognosis in these patients.

Materials and methods

This study recruited a total of 76 patients with International Federation of Gynaecology and Obstetrics (FIGO) stage IIB-IIIB CSCC. Mononuclear cells were isolated from the peripheral blood before any treatment and then enzyme-linked immun

SUBMITTER: Cai H 

PROVIDER: S-EPMC8447512 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature