Ontology highlight
ABSTRACT:
SUBMITTER: Smith MP
PROVIDER: S-EPMC8447605 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Smith Michael P MP Ferguson Harriet R HR Ferguson Jennifer J Zindy Egor E Kowalczyk Katarzyna M KM Kedward Thomas T Bates Christian C Parsons Joseph J Watson Joanne J Chandler Sarah S Fullwood Paul P Warwood Stacey S Knight David D Clarke Robert B RB Francavilla Chiara C
The EMBO journal 20210604 14
Integration of signalling downstream of individual receptor tyrosine kinases (RTKs) is crucial to fine-tune cellular homeostasis during development and in pathological conditions, including breast cancer. However, how signalling integration is regulated and whether the endocytic fate of single receptors controls such signalling integration remains poorly elucidated. Combining quantitative phosphoproteomics and targeted assays, we generated a detailed picture of recycling-dependent fibroblast gro ...[more]