Activation of neurotrophin signalling with light‑inducible receptor tyrosine kinases.

ABSTRACT: Optogenetics combined with protein engineering based on natural light‑sensitive dimerizing proteins has evolved as a powerful strategy to study cellular functions. The present study focused on tropomyosin kinase receptors (Trks) that have been engineered to be light‑sensitive. Trk belongs to the superfamily of receptor tyrosine kinases (RTKs), which are single‑pass transmembrane receptors that are activated by natural ligands and serve crucial roles in cellular growth, differentiation, metabolism and motility. However, functional variations exist among receptors fused with light‑sensitive proteins. The present study proposed a signal transduction model for light‑induced receptor activation. This model is based on analysis of previous light‑induced Trk receptors reported to date and compari

SUBMITTER: Zhang W 

PROVIDER: S-EPMC8767455 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature