Routine magnetoencephalography in memory clinic patients: A machine learning approach.
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ABSTRACT: Introduction
We report the routine application of magnetoencephalography (MEG) in a memory clinic, and its value in the discrimination of patients with Alzheimer's disease (AD) dementia from controls.Methods
Three hundred sixty-six patients visiting our memory clinic underwent MEG recording. Source-reconstructed MEG data were visually assessed and evaluated in the context of clinical findings and other diagnostic markers. We analyzed the diagnostic accuracy of MEG spectral measures in the discrimination of individual AD dementia patients (n = 40) from subjective cognitive decline (SCD) patients (n = 40) using random forest models.Results
Best discrimination was obtained using a combination of relative theta and delta power (accuracy 0.846, sensitivity 0.855, specificity 0.837). The results were validated in an independent cohort. Hippocampal and thalamic regions, besides temporal-occipital lobes, contributed considerably to the model.Discussion
MEG has been implemented successfully in the workup of memory clinic patients and has value in diagnostic decision-making.
SUBMITTER: Gouw AA
PROVIDER: S-EPMC8449227 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Routine magnetoencephalography in memory clinic patients: A machine learning approach.
Gouw Alida A AA Hillebrand Arjan A Schoonhoven Deborah N DN Demuru Matteo M Ris Peterjan P Scheltens Philip P Stam Cornelis J CJ
Alzheimer's & dementia (Amsterdam, Netherlands) 20210918 1
<h4>Introduction</h4>We report the routine application of magnetoencephalography (MEG) in a memory clinic, and its value in the discrimination of patients with Alzheimer's disease (AD) dementia from controls.<h4>Methods</h4>Three hundred sixty-six patients visiting our memory clinic underwent MEG recording. Source-reconstructed MEG data were visually assessed and evaluated in the context of clinical findings and other diagnostic markers. We analyzed the diagnostic accuracy of MEG spectral measur ...[more]
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