The expression and activity of Toll-like receptors in the preimplantation human embryo suggest a new role for innate immunity.
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ABSTRACT:
SUBMITTER: Aboussahoud WS
PROVIDER: S-EPMC8450873 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
The expression and activity of Toll-like receptors in the preimplantation human embryo suggest a new role for innate immunity.
Aboussahoud Wedad S WS Smith Helen H Stevens Adam A Wangsaputra Ivan I Hunter Helen R HR Kimber Susan J SJ Seif Mourad W MW Brison Daniel R DR
Human reproduction (Oxford, England) 20210901 10
<h4>Study question</h4>Is the innate immunity system active in early human embryo development?<h4>Summary answer</h4>The pattern recognition receptors and innate immunity Toll-like receptor (TLR) genes are widely expressed in preimplantation human embryos and the pathway appears to be active in response to TLR ligands.<h4>What is known already</h4>Early human embryos are highly sensitive to their local environment, however relatively little is known about how embryos detect and respond to specif ...[more]
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