Cannabidiol as a treatment for craving and relapse in individuals with cocaine use disorder: a randomized placebo-controlled trial.

ABSTRACT:

Background and aims

Cocaine use disorder (CUD) is a significant public health concern for which no efficacious pharmacological interventions are available. Cannabidiol (CBD) has attracted considerable interest as a promising treatment for addiction. This study tested CBD efficacy for reducing craving and preventing relapse in people with CUD.

Design

Single-site double-blind randomized controlled superiority trial comparing CBD with placebo.

Setting and participants

Centre Hospitalier de l'Université de Montréal, Canada. Seventy-eight adults (14 women) with moderate to severe CUD participated.

Intervention

Participants were randomly assigned (1 : 1) by stratified blocks to daily 800 mg CBD (n = 40) or placebo (n = 38). They first underwent an inpatient detoxific

SUBMITTER: Mongeau-Perusse V 

PROVIDER: S-EPMC8451934 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature